Why the study?
Does intra-arterial infusion of insulin alter forearm vascular resistance and reactivity to vasoconstrictors in normotensive and hypertensive subjects?
Population
Normotensive and hypertensive subjects.
Comparison
Intra-arterial infusion of insulin. vs Baseline/control state.
Design
Review
Authors
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May sustain hypertension via lost vascular protection; leaves open therapeutic targeting of insulin signaling.
Does intra-arterial infusion of insulin alter forearm vascular resistance and reactivity to vasoconstrictors in normotensive and hypertensive subjects?
Insulin exerts vasodilatory and anti-vasoconstrictor effects in normotensive individuals mediated by prostacyclin, but the loss of these protective mechanisms in hypertensive patients may contribute to the maintenance of hypertension.
Tsutomu Imaizumi (1996) studied this question.
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