Why the study?
Does intra-arterial infusion of insulin attenuate vasoconstrictive responses to phenylephrine and angiotensin II in patients with essential hypertension?
Population
7 male patients with essential hypertension, mean age 26 +/- 2 years, blood pressure 159 +/- 4/103 +/- 4…
Comparison
Intra-arterial infusion of human insulin into… vs Intra-arterial infusion of saline simultaneously…
Design
Other
Follow-up
Acute (during 1-hour infusion protocol)
Authors
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Suggests loss of insulin vascular protection in essential hypertension; leaves open hyperinsulinemia's role in sustaining blood pressure.
Does intra-arterial infusion of insulin attenuate vasoconstrictive responses to phenylephrine and angiotensin II in patients with essential hypertension?
The anti-vasoconstrictive effects of insulin on peripheral vessels are lost in patients with essential hypertension, suggesting hyperinsulinemia may contribute to the maintenance of hypertension via unopposed pressor effects.
Fujishima et al. (1995) studied this question.
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