Key result
Intra-arterial infusion of insulin significantly increased forearm blood flow from 1.86 to 3.64 mL dL-1 min-1 after 180 minutes (P<0.001), demonstrating a direct vascular vasodilator effect.
Why the study?
Does local intra-arterial insulin infusion increase forearm blood flow in healthy volunteers?
Population
20 healthy, lean, normotensive volunteers undergoing a total of 30 experiments
Comparison
Local, intra-arterial infusion of insulin into… vs Time and vehicle control experiments (n=5)
Design
Other
Follow-up
180 minutes
Authors
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No immediate clinical implications in healthy volunteers; leaves open relevance to insulin resistance or vascular disease.
Does local intra-arterial insulin infusion increase forearm blood flow in healthy volunteers?
p-value: p=<0.001
The slow vasodilator response to systemic insulin can be partly explained by a direct vascular effect of insulin, which is independent of skeletal muscle glucose uptake.
Tack et al. (1996) studied Healthy (n=20). Intra-arterial insulin infusion vs. Vehicle control was evaluated on Forearm blood flow (p=<0.001). Intra-arterial infusion of insulin significantly increased forearm blood flow from 1.86 to 3.64 mL dL-1 min-1 after 180 minutes (P<0.001), demonstrating a direct vascular vasodilator effect.
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