Key result
Brachial artery infusion of 5 mU/min insulin caused weak (20%) vasodilation compared with placebo (P<0.01), which was significantly augmented to 47% with D-glucose coinfusion.
Why the study?
Does local insulin infusion, alone or with D-glucose, improve forearm blood flow in healthy male volunteers?
Population
17 healthy male volunteers
Comparison
Brachial artery infusions of 1 mU/min or 5… vs Vehicle (placebo) brachial artery infusion
Design
RCT, random order on 3 separate study days, double blind, placebo-controlled
Follow-up
90 min
Authors
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Local glucose uptake determines insulin vasodilation in healthy men; extends mechanistic evidence for metabolic-vascular coupling.
RCT (n=17)
Double-blind
Random order
Does local insulin infusion, alone or with D-glucose, improve forearm blood flow in healthy male volunteers?
p-value: p=< 0.01
Local uptake of D-glucose by insulin-sensitive tissues is an important determinant of insulin-mediated vasodilation in healthy men.
Ueda et al. (1998) conducted an RCT in Healthy (n=17). Insulin alone or with D-glucose vs. Placebo (vehicle) was evaluated on Forearm blood flow (vasodilation) (p=< 0.01). Brachial artery infusion of 5 mU/min insulin caused weak (20%) vasodilation compared with placebo (P<0.01), which was significantly augmented to 47% with D-glucose coinfusion.
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