January 1, 2004Endothelium
Prolonged Local Forearm Hyperinsulinemia Induces Sustained Enhancement of Nitric Oxide–Dependent Vasodilation in Healthy Subjects
Why the study?
Does intra-arterial insulin infusion enhance nitric oxide-dependent vasodilation in healthy subjects?
Population
Healthy subjects, mean age 47.7 +/- 1.1 years (36 experiments performed)
Comparison
Intra-arterial insulin infused in the brachial… vs Vehicle
Design
Other
Follow-up
4 hours
Authors
Discussion
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Member takes
Implication
Prolonged local hyperinsulinemia directly causes a sustained, nitric oxide-mediated increase in endothelium-dependent vasodilation in resistance vessels of healthy subjects.
Structured PICO
Does intra-arterial insulin infusion enhance nitric oxide-dependent vasodilation in healthy subjects?
P
Population
Healthy subjects, mean age 47.7 +/- 1.1 years (36 experiments performed)
I
Intervention
Intra-arterial insulin infused in the brachial artery for 4 hours (240 min) at a constant rate
C
Comparator
Vehicle
O
Outcome
Endothelium-dependent and -independent vasodilation (measured by forearm blood flow via plethysmography)surrogate
Prolonged local hyperinsulinemia directly causes a sustained, nitric oxide-mediated increase in endothelium-dependent vasodilation in resistance vessels of healthy subjects.
Cite This Study
Hermann et al. (2004) studied this question.