Key result
Forearm vasodilation in response to local insulin/glucose infusion was significantly correlated with whole-body insulin sensitivity (rs=0.60, P<0.05).
Why the study?
Is there a functional relationship between insulin-mediated vasodilation and whole-body insulin sensitivity in healthy normotensive males?
Population
18 healthy, normotensive male volunteers (age, 26+/-5.4 years)
Design
Cross-sectional
Authors
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Should not change hypertension practice; hypothesis-generating for insulin resistance mechanisms in healthy men.
Cross-Sectional (n=18)
Is there a functional relationship between insulin-mediated vasodilation and whole-body insulin sensitivity in healthy normotensive males?
Effect estimate: rs=0.60
p-value: p=<0.05
There is a significant functional relationship between insulin's metabolic actions (glucose uptake) and vascular actions (vasodilation) in healthy humans.
Cleland et al. (1999) conducted a cross-sectional in Healthy (n=18). Intra-arterial infusion of insulin/glucose was evaluated on Relationship between whole-body insulin sensitivity and forearm vasodilation (rs=0.60, p=<0.05). Forearm vasodilation in response to local insulin/glucose infusion was significantly correlated with whole-body insulin sensitivity (rs=0.60, P<0.05).
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