What question did this study set out to answer?

To determine whether insulin sensitivity modulates the effect of muscle perfusion on glucose uptake and whether this mechanism operates via capillary recruitment.

May 1, 2000DiabetesOpen Access

Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment.

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Why the study?

Does modulating muscle perfusion alter insulin-mediated glucose uptake across different levels of insulin sensitivity?

Population

Human subjects exhibiting a wide range of insulin sensitivity

Comparison

Steady-state euglycemic hyperinsulinemia for 4… vs Baseline steady-state euglycemic…

Follow-up

4 hours

Authors

ABA. D. BaronVascular Medicine MTManal TarshobyMansoura University GHGinger HookBarrow Neurological Institute

Discussion

Member takes

Implication

Muscle perfusion may enhance glucose uptake in an insulin sensitivity-dependent manner; leaves open whether targeting it improves metabolic outcomes.

Key Points

To determine whether insulin sensitivity modulates the effect of muscle perfusion on glucose uptake and whether this mechanism operates via capillary recruitment.
Measured glucose disposal rates and leg glucose uptake during 4-hour euglycemic-hyperinsulinemic clamps (>6,000 pmol/l) across subjects with varied insulin sensitivity.
Doubled leg blood flow via intrafemoral infusion of methacholine chloride measured by thermodilution, and compared flow-mediated extraction changes against the Renkin model using methacholine or N(G)-monomethyl-L-arginine.
Methacholine infusion elevated leg blood flow by 114 ± 12%, reduced arteriovenous glucose difference by 32 ± 4%, and increased overall leg glucose uptake by 40 ± 5% (P < 0.05).
The perfusion-induced increase in leg glucose uptake correlated positively with baseline insulin sensitivity (r = 0.60, P < 0.02).
Arteriovenous glucose differences across altered blood flow levels showed smaller drops than predicted by the Renkin noncapillary recruitment model, confirming microvascular recruitment.

Structured PICO

Does modulating muscle perfusion alter insulin-mediated glucose uptake across different levels of insulin sensitivity?

Population

Human subjects exhibiting a wide range of insulin sensitivity

Intervention

Steady-state euglycemic hyperinsulinemia (>6,000 pmol/l) for 4 hours, followed by intrafemoral artery infusion of methacholine chloride or N(G)-monomethyl-L-arginine to modulate leg blood flow

Comparator

Baseline steady-state euglycemic hyperinsulinemia prior to perfusion modulation

Outcome

Glucose disposal rates (GDRs) and leg muscle glucose uptake (LGU)surrogate

Muscle perfusion becomes more rate-limiting to glucose uptake as insulin sensitivity increases, and insulin-mediated increments in muscle perfusion involve capillary recruitment.

Cite This Study

Baron et al. (2000) studied this question.

synapsesocial.com/papers/69db23cf1e19c8ae08836ab7 https://doi.org/10.2337/diabetes.49.5.768

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Implication

Muscle perfusion may enhance glucose uptake in an insulin sensitivity-dependent manner; leaves open whether targeting it improves metabolic outcomes.

Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider