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February 1, 2004DiabetesOpen Access

Insulin Sensitivity of Muscle Capillary Recruitment In Vivo

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Population

Fed hooded Wistar and fasted Sprague-Dawley rats

Comparison

Insulin infusion (doses between 0 and 30 mU… vs Basal levels (0 dose) or different insulin doses

Design

Preclinical

Follow-up

2 hours

Authors

MVMichelle A. VincentUniversity of VirginiaSRStephen M. RichardsUniversity of TasmaniaLCLucy H. ClerkUniversity of Virginia

Discussion

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Implication

Suggests microvascular insulin sensitivity precedes bulk flow changes in diabetes models; leaves open human translation and therapeutic targeting.

Structured PICO

P
Population
Fed hooded Wistar and fasted Sprague-Dawley rats
I
Intervention
Insulin infusion (doses between 0 and 30 mU(-1). min(-1). kg(-1)) during hyperinsulinemic-euglycemic clamp
C
Comparator
Basal levels (0 dose) or different insulin doses
O
Outcome
Muscle microvascular recruitment (measured by 1-MX metabolism or CEU), femoral blood flow, and hindleg glucose uptake at 2 hourssurrogate

Precapillary arterioles regulating microvascular recruitment are more sensitive to insulin than resistance arterioles regulating total blood flow.

Cite This Study

Vincent et al. (2004) studied this question.

synapsesocial.com/papers/6a7de9e233dcb27c99cb6085https://doi.org/10.2337/diabetes.53.2.447
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Skeletal Muscle Microvascular Recruitment by Physiological Hyperinsulinemia Precedes Increases in Total Blood Flow2002 · 221 citations
  2. 2Blood flow and muscle metabolism: a focus on insulin action2003 · 359 citations
  3. 3Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin2003 · 307 citations
  4. 4Delayed Transcapillary Transport of Insulin to Muscle Interstitial Fluid in Obese Subjects2002 · 115 citations
  5. 5Dose-response curves for in vivo insulin sensitivity in individual tissues in rats1985 · 414 citations