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November 1, 1996Diabetes

Evidence for Dissociation of Insulin Stimulation of Blood Flow and Glucose Uptake in Human Skeletal Muscle: Studies Using 15OH2O, 18Ffluoro-2-deoxy- D -glucose, and Positron Emission Tomography

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Why the study?

Does high-dose insulin infusion affect regional femoral muscle blood flow and glucose uptake in healthy volunteers?

Population

14 healthy volunteers, mean age 34 +/- 8 years, BMI 24.6 +/- 3.4 kg/m2

Comparison

140-min high-dose insulin infusion under… vs Basal state (before insulin infusion)

Design

Other

Follow-up

140 minutes

Authors

MRMaria RaitakariÅbo Akademi UniversityPNPirjo NuutilaCardiac ImagingURUlla RuotsalainenÅbo Akademi University

Discussion

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Implication

Suggests independent regulation of insulin's vascular and metabolic effects; hypothesis-generating and should not change practice.

Structured PICO

Does high-dose insulin infusion affect regional femoral muscle blood flow and glucose uptake in healthy volunteers?

P
Population
14 healthy volunteers, mean age 34 +/- 8 years, BMI 24.6 +/- 3.4 kg/m2
I
Intervention
140-min high-dose insulin infusion under normoglycemic conditions
C
Comparator
Basal state (before insulin infusion)
O
Outcome
Regional femoral muscle blood flow and glucose uptakesurrogate

Insulin-stimulated rates of blood flow and glucose uptake do not colocalize in the same regions of muscle tissue, suggesting differential regulation of its hemodynamic and metabolic effects.

Cite This Study

Raitakari et al. (1996) studied this question.

synapsesocial.com/papers/6a95daf046cd8039cb92c7c8https://doi.org/10.2337/diab.45.11.1471
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Insulin increases blood volume in human skeletal muscle: studies using [15O]CO and positron emission tomography1995 · 56 citations
  2. 2Intact insulin stimulation of skeletal muscle blood flow, its heterogeneity and redistribution, but not of glucose uptake in non-insulin-dependent diabetes mellitus.1997 · 76 citations
  3. 3Skeletal Muscle Microvascular Recruitment by Physiological Hyperinsulinemia Precedes Increases in Total Blood Flow2002 · 221 citations
  4. 4Evidence for Spatial Heterogeneity in Insulin- and Exercise-Induced Increases in Glucose Uptake: Studies in Normal Subjects and Patients with Type 1 Diabetes2001 · 14 citations
  5. 5Hyperinsulinemia Rapidly Increases Human Muscle Microvascular Perfusion but Fails to Increase Muscle Insulin Clearance2007 · 89 citations