December 1, 1995AJP Endocrinology and Metabolism
Insulin increases blood volume in human skeletal muscle: studies using 15OCO and positron emission tomography
Why the study?
Does euglycemic hyperinsulinemia increase skeletal muscle blood volume in normal subjects?
Population
14 normal subjects, mean age 35 +/- 3 years, BMI 24.9 +/- 1.3 kg/m2
Comparison
Euglycemic hyperinsulinemia vs Basal state (within-subject comparison)
Design
Other
Authors
Discussion
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Member takes
Implication
Indicates insulin's vasodilatory action on human muscle microvasculature; leaves open relevance to insulin-resistant states and clinical outcomes.
Structured PICO
Does euglycemic hyperinsulinemia increase skeletal muscle blood volume in normal subjects?
P
Population
14 normal subjects, mean age 35 +/- 3 years, BMI 24.9 +/- 1.3 kg/m2 (an additional 5 normal subjects were used for reproducibility testing)
I
Intervention
Euglycemic hyperinsulinemia (serum insulin 3,200 +/- 190 pmol/l)
C
Comparator
Basal state (within-subject comparison)
O
Outcome
Skeletal muscle blood volume in the femoral region measured by positron emission tomography combined with inhalation of [15O]carbon monoxidesurrogate
High insulin concentrations exert a true vasodilatory effect, increasing blood volume in human skeletal muscle.
Cite This Study
Raitakari et al. (1995) studied this question.