Effects of Blood Glucose Concentration on Thermogenesis and Glucose Disposal during Hyperinsulinaemia

10 healthy post-absorptive subjects (six male, aged 21–30 years)

Hyperinsulinaemic glucose clamp (100 m-units min−1 m−2 continuous insulin infusion for 90 min) maintaining arterialized venous blood glucose concentration at 4.5 mmol/l (euglycaemia)

Hyperinsulinaemic glucose clamp maintaining arterialized venous blood glucose concentration at 3.5 mmol/l (mild hypoglycaemia)

Rates of glucose disposal, glucose storage, and metabolic rate during the final 30 min of the hyperinsulinaemic clampsurrogate