What question did this study set out to answer?

To determine the autonomic regulatory and haemodynamic responses to acute hyperinsulinaemia and subsequent hypoglycaemia in healthy individuals.

September 1, 2003Clinical Science

Effects of euglycaemic and hypoglycaemic hyperinsulinaemia on sympathetic and parasympathetic regulation of haemodynamics in healthy subjects

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Why the study?

Does hyperinsulinaemic hypoglycaemia alter sympathetic and parasympathetic regulation of haemodynamics in healthy subjects?

Population

18 healthy subjects

Comparison

Hyperinsulinaemic clamp with euglycaemic and… vs Baseline

Design

Other

Authors

TLTomi LaitinenTulane University HHHanna HuopioKuopio University Hospital IVIlkka VauhkonenNovo Nordisk (Finland)

Discussion

Member takes

Implication

May inform haemodynamic monitoring during hypoglycaemia; hypothesis-generating for patients with diabetes or cardiovascular disease.

Key Points

To determine the autonomic regulatory and haemodynamic responses to acute hyperinsulinaemia and subsequent hypoglycaemia in healthy individuals.
Evaluated 18 healthy subjects at baseline and during both the euglycaemic and hypoglycaemic phases of a hyperinsulinaemic clamp.
Assessed heart rate variability and blood pressure variability via power spectral analysis, baroreflex sensitivity using the cross-spectral method, and stroke volume via arterial pulse contour analysis.
Euglycaemic hyperinsulinaemia produced no significant changes in catecholamine concentrations, autonomic variability indices, baroreflex sensitivity, blood pressure, or cardiac output.
Hyperinsulinaemic hypoglycaemia drove an 11.7-fold increase in plasma adrenaline (from 0.19±0.03 to 1.68±0.32 nmol/l; P<0.001) and a 1.3-fold increase in noradrenaline (from 1.74±0.22 to 2.02±0.19 nmol/l; P<0.05).
Hypoglycaemia reduced diastolic blood pressure (from 68±3 to 60±3 mmHg; P<0.05) and peripheral resistance (from 24.1±1.2 to 18.5±1.1 mmHg·min⁻¹·l⁻¹; P<0.01) while increasing stroke volume and cardiac output (P<0.01 for both), without altering heart rate variability or baroreflex sensitivity.

Structured PICO

Does hyperinsulinaemic hypoglycaemia alter sympathetic and parasympathetic regulation of haemodynamics in healthy subjects?

Population

18 healthy subjects

Intervention

Hyperinsulinaemic clamp with euglycaemic and hypoglycaemic phases

Comparator

Baseline

Outcome

Regulatory and haemodynamic responses (heart rate variability, blood pressure variability, baroreflex sensitivity, stroke volume, cardiac output, peripheral resistance, plasma catecholamines, heart rate, blood pressure)surrogate

Hyperinsulinaemic hypoglycaemia induces selective adrenomedullary sympathetic activation and decreases peripheral resistance and blood pressure without altering cardiac parasympathetic regulation or baroreflex control.

Cite This Study

Laitinen et al. (2003) studied this question.

synapsesocial.com/papers/6a7167518031ec7bb1dcf410 https://doi.org/10.1042/cs20030079

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Effects of euglycaemic and hypoglycaemic hyperinsulinaemia on sympathetic and parasympathetic regulation of haemodynamics in healthy subjects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of euglycaemic and hypoglycaemic hyperinsulinaemia on sympathetic and parasympathetic regulation of haemodynamics in healthy subjects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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