Why the study?
Does insulin-induced hypoglycaemia alter cardiac autonomic activity and heart rate variability in healthy humans?
Population
15 healthy volunteers (7 male; mean age 27 years)
Comparison
Hypoglycaemic (2.7 mmol/l) hyperinsulinaemic clamp vs Normoglycaemic hyperinsulinaemic clamp
Design
RCT, randomized cross-over design, single-blind
Follow-up
1 hour
Authors
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Hypoglycaemia activates opposing sympathetic and parasympathetic cardiac effects that stabilize mean heart rate; extends mechanistic understanding of autonomic balance during metabolic stress.
Does insulin-induced hypoglycaemia alter cardiac autonomic activity and heart rate variability in healthy humans?
Insulin-induced hypoglycaemia triggers both sympathetic and parasympathetic activation in healthy adults, which stabilizes the mean heart rate.
Schächinger et al. (2004) studied this question.
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