March 1, 1996Clinical Science
Effect of Hyperglycaemia on Arterial Pressure, Plasma Renin Activity and Renal Function in Early Diabetes
Key result
A 12-hour period of hyperglycaemia significantly increased baseline plasma renin activity (3.82 vs 2.13 pmol/h/ml, P=0.009) and mean arterial pressure (89 vs 81 mmHg, P=0.03) compared to euglycaemia.
Why the study?
Does hyperglycaemia increase arterial pressure, plasma renin activity, and alter renal haemodynamics in males with early insulin-dependent diabetes mellitus?
Population
11 males with insulin-dependent diabetes mellitus, within 6 years of diagnosis
Comparison
12-hour period of induced hyperglycaemia vs Euglycaemia (4.0-6.0 mmol/l)
Design
Other
Follow-up
12 hours
Authors
Discussion
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Implication
Acute hyperglycaemia may activate the renin-angiotensin system in early diabetes; hypothesis-generating for microvascular complications.
Structured PICO
Does hyperglycaemia increase arterial pressure, plasma renin activity, and alter renal haemodynamics in males with early insulin-dependent diabetes mellitus?
P
Population
11 males with insulin-dependent diabetes mellitus within 6 years of diagnosis, examined during euglycaemia and after 12 hours of hyperglycaemia.
I
Intervention
12-hour period of induced hyperglycaemia (8.5-10.5 mmol/l)
C
Comparator
Euglycaemia (4.0-6.0 mmol/l)
O
Outcome
Plasma renin activity and mean arterial pressure at rest and during simulated orthostatic stresssurrogate
Main Result
Absolute Event Rate: 3.82% vs 2.13%
p-value: p=0.009
Sustained hyperglycaemia in early insulin-dependent diabetes activates the renin-angiotensin system and increases systemic and renal vasomotor tone, which may contribute to long-term microvascular complications.
Cite This Study
Miller et al. (1996) studied insulin-dependent diabetes mellitus (n=11). Hyperglycaemia vs. Euglycaemia (4.0-6.0 mmol/l) was evaluated on Plasma renin activity at baseline (p=0.009). A 12-hour period of hyperglycaemia significantly increased baseline plasma renin activity (3.82 vs 2.13 pmol/h/ml, P=0.009) and mean arterial pressure (89 vs 81 mmHg, P=0.03) compared to euglycaemia.