February 1, 1994AJP Regulatory Integrative and Comparative Physiology
Abnormalities in the renal and vascular responses to LBNP in humans with early diabetes
Why the study?
Does LBNP-induced reduction of plasma ANF alter renal and vascular responses differently in subjects with early IDDM compared to normal controls?
Population
Subjects with early, uncomplicated, well-controlled insulin-dependent diabetes mellitus and normal control…
Comparison
Nonhypotensive lower body negative pressure (LBNP) vs Normal control subjects undergoing the same LBNP
Design
Cross-sectional
Authors
Discussion
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Implication
Early IDDM shows attenuated GFR decline during LBNP; hypothesis-generating for ANF role in diabetic kidney disease.
Structured PICO
Does LBNP-induced reduction of plasma ANF alter renal and vascular responses differently in subjects with early IDDM compared to normal controls?
P
Population
Subjects with early, uncomplicated, well-controlled insulin-dependent diabetes mellitus (IDDM) and normal control subjects
I
Intervention
Nonhypotensive lower body negative pressure (LBNP)
C
Comparator
Normal control subjects undergoing the same LBNP
O
Outcome
Response of renal blood flow (RBF), glomerular filtration rate (GFR), filtration fraction (FF), and urinary sodium excretion (UNaV) to a reduction of plasma ANF concentrations induced by LBNPsurrogate
Subjects with early IDDM exhibit attenuated renal and vascular responses to LBNP-induced reductions in plasma ANF compared to healthy controls.
Cite This Study
Miller et al. (1994) studied this question.