Why the study?
Does atrial natriuretic peptide (ANP) mediate glomerular hyperfiltration in the early stages of insulin-dependent diabetes mellitus in rats?
Population
Spontaneously diabetes-prone (BB/DP) rats and age-matched diabetes-resistant (BB/DR) rats
Comparison
ANP receptor antagonist infusion vs Baseline measurements and age-matched…
Design
Preclinical
Follow-up
14 days after onset of IDDM
Authors
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ANP antagonism lowers MAP without affecting GFR in diabetic rats; leaves open whether ANP mediates hyperfiltration in human diabetes.
Does atrial natriuretic peptide (ANP) mediate glomerular hyperfiltration in the early stages of insulin-dependent diabetes mellitus in rats?
Atrial natriuretic peptide does not appear to be the primary mediator of glomerular hyperfiltration in the early stages of insulin-dependent diabetes mellitus in this rat model.
Okwueze et al. (1994) studied this question.
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