Population
Wistar rats with experimental diabetes induced by streptozocin injection, studied 6-8 weeks post-injection
Comparison
Specific ANP-antiserum infusion, indomethacin… vs Preinfusion values, normoglycemic diabetic rats…
Design
Preclinical
Follow-up
6-8 weeks after streptozocin injection
Authors
Loading...
Hypothesis-generating for ANP-prostacyclin synergy in diabetic hyperfiltration; does not support practice change in humans.
Atrial natriuretic peptide and prostacyclin synergistically mediate renal hyperfiltration and hyperperfusion in experimental diabetic rats.
Perico et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: