Why the study?
Does intravenous infusion of α-human atrial natriuretic peptide differentially affect systemic and renal hemodynamics and renal excretory function in patients with type I diabetes mellitus compared to healthy controls?
Population
12 subjects total: 6 insulin-treated and metabolically well-controlled patients with diabetes mellitus type…
Comparison
1 hour intravenous infusion of α-human atrial… vs Healthy control subjects receiving the identical…
Design
Cohort
Follow-up
1 hour (duration of infusion)
Authors
Loading...
May alter volume regulation in type 1 DM; leaves open ANP pathway targeting for future trials.
Does intravenous infusion of α-human atrial natriuretic peptide differentially affect systemic and renal hemodynamics and renal excretory function in patients with type I diabetes mellitus compared to healthy controls?
The renal vasculature in patients with type I diabetes mellitus exhibits heightened sensitivity to circulating atrial natriuretic peptide, leading to exaggerated increases in glomerular filtration rate and natriuresis compared to healthy individuals.
Predel et al. (1990) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: