Why the study?
Does angiotensin II infusion alter renal hemodynamics differently in early Type 1 diabetic patients compared to non-diabetic controls?
Population
18 subjects: 9 euglycaemic Type 1 diabetic patients with short duration of disease and 9 non-diabetic…
Comparison
Infusion of sub-pressor doses of angiotensin II vs Non-diabetic control subjects receiving the same…
Design
Other
Authors
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Supports normal renal hemodynamics in early Type 1 diabetes; leaves open generalizability to larger cohorts or advanced disease.
Does angiotensin II infusion alter renal hemodynamics differently in early Type 1 diabetic patients compared to non-diabetic controls?
The renal haemodynamic response to angiotensin II infusion is normal in early well-controlled Type 1 diabetes, suggesting no altered renal tubular responses to angiotensin II.
Eadington et al. (1991) studied this question.