Why the study?
Does Angiotensin II infusion improve insulin sensitivity and skeletal muscle blood flow in patients with recent-onset type 2 diabetes compared to healthy volunteers?
Population
27 subjects, including 12 healthy volunteers and 15 patients with type 2 diabetes mellitus of recent onset.
Comparison
Infusion of 2 ng Angiotensin II/kg per min vs Sham infusion (placebo)
Design
RCT, Allocated in random order, Double-blind, placebo-controlled
Follow-up
Acute (during infusion)
Authors
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Ang II fails to boost insulin sensitivity in recent-onset T2D; challenges assumptions of uniform effects and extends evidence of attenuated responses versus controls.
Does Angiotensin II infusion improve insulin sensitivity and skeletal muscle blood flow in patients with recent-onset type 2 diabetes compared to healthy volunteers?
The stimulatory effect of Angiotensin II on insulin sensitivity and skeletal muscle blood flow is attenuated in patients with recent-onset type 2 diabetes compared to healthy volunteers.
Fliser et al. (1997) studied this question.
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