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November 1, 1997Hypertension

Angiotensin II Affects Basal, Pulsatile, and Glucose-Stimulated Insulin Secretion in Humans

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Why the study?

Does Angiotensin II affect basal, pulsatile, and glucose-stimulated insulin secretion in healthy volunteers?

Population

19 healthy volunteers (17 male; mean age, 26+/-1 years) after an overnight fast.

Comparison

Infusion of Angiotensin II at 1.0 ng/kg/min and… vs Solvent (placebo) infusion.

Design

RCT, Allocated on three occasions in random order, Double-blind…

Follow-up

120 minutes

Authors

DFDanilo FliserPreventive CardiologyFSFranz SchaeferTulane UniversityDSDaniela SchmidAlbstadt-Sigmaringen University

Discussion

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Implication

Ang II impairs insulin secretion and glucose tolerance in healthy adults; extends causal evidence for RAS effects on beta-cell function and supports targeted trials in hypertension.

Structured PICO

Does Angiotensin II affect basal, pulsatile, and glucose-stimulated insulin secretion in healthy volunteers?

P
Population
19 healthy volunteers (17 male; mean age, 26+/-1 years) after an overnight fast.
I
Intervention
Infusion of Angiotensin II at 1.0 ng/kg/min (subpressor dose) and 5.0 ng/kg/min (pressor dose).
C
Comparator
Solvent (placebo) infusion.
O
Outcome
Plasma insulin concentrations over a period of 120 minutes to assess basal and pulsatile insulin secretion.surrogate

Angiotensin II infusion significantly reduces basal, pulsatile, and glucose-stimulated insulin secretion in healthy humans, suggesting a potential mechanism linking Ang II, hyperinsulinemia, and hypertension.

Cite This Study

Fliser et al. (1997) studied this question.

synapsesocial.com/papers/6a71f12835aa2c282ce302f7https://doi.org/10.1161/01.hyp.30.5.1156
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Opposing Actions of Angiotensin II on Microvascular Growth and Arterial Blood Pressure1996 · 288 citations
  2. 2A comparison between enalapril and captopril on insulin sensitivity in normotensive healthy volunteers1993 · 12 citations
  3. 3Glucose clamp technique: a method for quantifying insulin secretion and resistance.1979 · 7,488 citations
  4. 4Effects of Angiotensin Receptor Antagonist and Angiotensin Converting Enzyme Inhibitor on Insulin Sensitivity in Fructose-Fed Hypertensive Rats and Essential Hypertensives1995 · 128 citations