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September 1, 1993Journal of Hypertension

Angiotensin II enhances insulin sensitivity in healthy volunteers under euglycemic conditions

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Why the study?

Does Angiotensin II infusion improve insulin-mediated glucose uptake in healthy volunteers?

Population

8 healthy volunteers

Comparison

Infusion of Angiotensin II, with or without 3… vs Sham infusion

Design

RCT, Allocated in random order

Authors

DFDanilo FliserPreventive CardiologyUAUrsula ArnoldSwansea UniversityBKBrigitte KohlHeidelberg University

Discussion

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Implication

Ang II infusion enhances insulin sensitivity in healthy volunteers; extends RAAS effects on glucose metabolism beyond hemodynamics.

Structured PICO

Does Angiotensin II infusion improve insulin-mediated glucose uptake in healthy volunteers?

P
Population
8 healthy volunteers
I
Intervention
Infusion of Angiotensin II (first 0.75 ng/kg per min and subsequently 1.5 ng/kg per min), with or without 3 days of indomethacin pretreatment (150 mg/day)
C
Comparator
Sham infusion
O
Outcome
Insulin-mediated glucose uptake (M value) measured with the euglycemic clamp techniquesurrogate

Subpressor doses of Angiotensin II enhance insulin sensitivity in healthy volunteers by mechanisms independent of prostaglandins.

Cite This Study

Fliser et al. (1993) studied this question.

synapsesocial.com/papers/6a6f7f7c8031ec7bb1dbc7echttps://doi.org/10.1097/00004872-199309000-00013
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Angiotensin II on Insulin Sensitivity: A Placebo-Controlled Study1993 · 14 citations
  2. 2Opposing Effects of Angiotensin II on Muscle and Renal Blood Flow under Euglycemic Conditions2000 · 26 citations
  3. 3Opposing effects of angiotensin II on muscle and renal blood flow under euglycemic conditions2000 · 2 citations
  4. 4Altered action of angiotensin II in patients with type 2 diabetes mellitus of recent onset1997 · 16 citations
  5. 5Angiotensin II induces insulin resistance independent of changes in interstitial insulin1999 · 104 citations