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October 1, 1993Clinical Science

Effects of Angiotensin II on Insulin Sensitivity: A Placebo-Controlled Study

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Why the study?

Does acute infusion of angiotensin II affect whole-body insulin sensitivity in healthy male subjects?

Population

12 healthy male subjects

Comparison

Acute infusion of angiotensin II for 3 hours at… vs Placebo infusion

Design

RCT, Randomized, Double-blind

Follow-up

3 hours

Authors

AMA. D. MorrisWestern InfirmaryJPJ. R. PetrieWestern InfirmaryJAJohn H. AndersonInstituto Alexander Fleming

Discussion

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Implication

Acute angiotensin II infusion does not alter insulin sensitivity in healthy men; confirms acute neutrality and leaves open chronic or diseased-state effects.

Structured PICO

Does acute infusion of angiotensin II affect whole-body insulin sensitivity in healthy male subjects?

P
Population
12 healthy male subjects
I
Intervention
Acute infusion of angiotensin II for 3 hours at subpressor (1 ng/min/kg) and pressor (5 ng/min/kg) doses
C
Comparator
Placebo infusion
O
Outcome
Whole-body insulin sensitivity measured using the euglycaemic hyperinsulinaemic clampsurrogate

Acute infusion of angiotensin II, even at pressor doses, does not affect whole-body insulin sensitivity in healthy men.

Cite This Study

Morris et al. (1993) studied this question.

synapsesocial.com/papers/6a716f77f44fa9f079df3dc4https://doi.org/10.1042/cs0850431
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II enhances insulin sensitivity in healthy volunteers under euglycemic conditions1993 · 37 citations
  2. 2Pressor and Subpressor Doses of Angiotensin II Increase Insulin Sensitivity in NIDDM: Dissociation of Metabolic and Blood Pressure Effects1994 · 36 citations
  3. 3Angiotensin II Affects Basal, Pulsatile, and Glucose-Stimulated Insulin Secretion in Humans1997 · 55 citations
  4. 4Opposing Effects of Angiotensin II on Muscle and Renal Blood Flow under Euglycemic Conditions2000 · 26 citations
  5. 5Opposing effects of angiotensin II on muscle and renal blood flow under euglycemic conditions2000 · 2 citations