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November 1, 2000Journal of the American Society of Nephrology

Opposing Effects of Angiotensin II on Muscle and Renal Blood Flow under Euglycemic Conditions

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Why the study?

Does Angiotensin II infusion alter skeletal muscle and renal blood flow under euglycemic conditions in healthy male volunteers?

Population

9 healthy male volunteers, mean age 24 +/- 2 years.

Comparison

Infusion of 5 ng Angiotensin II/kg per min, with… vs Placebo premedication per os plus placebo…

Design

RCT, allocated in random order, double-blind, placebo-controlled

Authors

DFDanilo FliserPreventive CardiologyRDRalf DikowInternational University in GermanySDSadri DemukajKreiskrankenhaus Dormagen

Discussion

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Implication

Ang II's muscle perfusion and insulin-sensitivity gains merit consideration in metabolic research; confirms AT1-mediated opposing regional hemodynamic effects.

Structured PICO

Does Angiotensin II infusion alter skeletal muscle and renal blood flow under euglycemic conditions in healthy male volunteers?

P
Population
9 healthy male volunteers, mean age 24 +/- 2 years.
I
Intervention
Infusion of 5 ng Angiotensin II/kg per min, with or without premedication with 300 mg of the angiotensin II-1-receptor antagonist irbesartan per os.
C
Comparator
Placebo premedication per os plus placebo infusion.
O
Outcome
Insulin-stimulated glucose uptake (M value) and leg muscle blood flow.surrogate

Angiotensin II has opposing effects on regional arterial blood flow under hyperinsulinemic euglycemic conditions, increasing skeletal muscle blood flow while causing renal vasoconstriction, both mediated by AT1 receptors.

Cite This Study

Fliser et al. (2000) studied this question.

synapsesocial.com/papers/6a71f12835aa2c282ce302f6https://doi.org/10.1681/asn.v11112001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II enhances insulin sensitivity in healthy volunteers under euglycemic conditions1993 · 37 citations
  2. 2Altered action of angiotensin II in patients with type 2 diabetes mellitus of recent onset1997 · 16 citations
  3. 3Low-Dose Angiotensin II Increases Glucose Disposal Rate During Euglycemic Hyperinsulinemia1993 · 23 citations
  4. 4Angiotensin II Affects Basal, Pulsatile, and Glucose-Stimulated Insulin Secretion in Humans1997 · 55 citations
  5. 5Dose-response study of the redistribution of intravascular volume by angiotensin II in man1992 · 25 citations