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September 4, 2018Cardiovascular ResearchOpen Access

Acute, local infusion of angiotensin II impairs microvascular and metabolic insulin sensitivity in skeletal muscle

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Why the study?

Does acute infusion of Angiotensin II impair microvascular and metabolic insulin sensitivity in skeletal muscle in rats?

Population

Adult, male Sprague-Dawley rats

Comparison

Acute systemic or local infusion of Angiotensin… vs Systemic infusion of saline or insulin alone

Design

Preclinical

Follow-up

Acute

Authors

DPDino PremilovacUniversity of TasmaniaEAEmily AttrillUniversity of TasmaniaSRStephen RattiganGeneral / Preventive / Lipids

Discussion

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Implication

Acute AngII attenuates microvascular insulin action in rat muscle; hypothesis-generating for hypertension-insulin resistance links, no practice change.

Structured PICO

Does acute infusion of Angiotensin II impair microvascular and metabolic insulin sensitivity in skeletal muscle in rats?

P
Population
Adult, male Sprague-Dawley rats
I
Intervention
Acute systemic or local infusion of Angiotensin II (AngII) during hyperinsulinaemic euglycaemic clamp
C
Comparator
Systemic infusion of saline or insulin alone
O
Outcome
Microvascular blood flow and skeletal muscle glucose uptakesurrogate

Acute local and systemic Angiotensin II infusion attenuates insulin's microvascular actions in skeletal muscle, suggesting a mechanism linking microvascular insulin resistance and hypertension.

Cite This Study

Premilovac et al. (2018) studied this question.

synapsesocial.com/papers/6a856b19a46f793aa75e247fhttps://doi.org/10.1093/cvr/cvy225
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Direct vasodilator effects of physiological hyperinsulin‐aemia in human skeletal muscle1996 · 49 citations
  2. 2Evidence for Dissociation of Insulin Stimulation of Blood Flow and Glucose Uptake in Human Skeletal Muscle: Studies Using [15O]H2O, [18F]fluoro-2-deoxy- D -glucose, and Positron Emission Tomography1996 · 61 citations
  3. 3Insulin Sensitivity of Muscle Capillary Recruitment In Vivo2004 · 162 citations
  4. 4The renin‐angiotensin system: a link between obesity, inflammation and insulin resistance2011 · 279 citations
  5. 5Microvascular Dysfunction in Obesity: A Potential Mechanism in the Pathogenesis of Obesity-Associated Insulin Resistance and Hypertension2007 · 279 citations