Key result
Local Angiotensin II infusion maintained steady glucose utilization (4% decrease, P=NS) by increasing glucose extraction by 59% (P<.05) to compensate for a 38% decrease in forearm blood flow (P<.05).
Why the study?
Does local Angiotensin II infusion directly impair insulin-stimulated glucose utilization in healthy subjects?
Population
20 healthy subjects
Comparison
Local infusion of Angiotensin II into the… vs Insulin alone
Design
Other
Follow-up
90 minutes
Authors
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Local Ang II effects on forearm glucose handling warrant no practice change; leaves open systemic metabolic implications in hypertension.
Does local Angiotensin II infusion directly impair insulin-stimulated glucose utilization in healthy subjects?
Effect estimate: 4% decrease
p-value: p=NS
Local Angiotensin II infusion does not directly impair insulin-stimulated glucose utilization, suggesting that previously observed effects on glucose uptake are mediated by hemodynamic factors rather than direct metabolic effects.
Jamerson et al. (1996) studied Healthy (n=20). Local infusion of Angiotensin II vs. Insulin alone (first 60 minutes) was evaluated on Glucose utilization (4% decrease, p=NS). Local Angiotensin II infusion maintained steady glucose utilization (4% decrease, P=NS) by increasing glucose extraction by 59% (P<.05) to compensate for a 38% decrease in forearm blood flow (P<.05).
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