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October 1, 1993American Journal of Hypertension

Low-Dose Angiotensin II Increases Glucose Disposal Rate During Euglycemic Hyperinsulinemia

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Why the study?

Does low-dose angiotensin II infusion alter glucose disposal rate and calf blood flow in healthy men during euglycemic hyperinsulinemia?

Population

39 healthy men

Comparison

Angiotensin II infusion at a low dose during… vs Euglycemic hyperinsulinemia alone

Design

Other

Authors

BWBengt R. WidgrenSahlgrenska University HospitalVUVaidotas UrbanavičiusLithuanian University of Health SciencesJWJohn WikstrandUniversity of North Carolina at Chapel Hill

Discussion

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Implication

May enhance insulin sensitivity independent of blood flow in healthy men; leaves open relevance to hypertension or diabetes.

Structured PICO

Does low-dose angiotensin II infusion alter glucose disposal rate and calf blood flow in healthy men during euglycemic hyperinsulinemia?

P
Population
39 healthy men
I
Intervention
Angiotensin II infusion at a low dose (0.1 ng/kg/min) during euglycemic hyperinsulinemia
C
Comparator
Euglycemic hyperinsulinemia alone
O
Outcome
Glucose disposal rate and calf blood flowsurrogate

Low-dose angiotensin II stimulates insulin-mediated glucose uptake in healthy men, an effect that appears independent of changes in blood flow.

Cite This Study

Widgren et al. (1993) studied this question.

synapsesocial.com/papers/6a716f77f44fa9f079df3dc3https://doi.org/10.1093/ajh/6.10.892
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Opposing Effects of Angiotensin II on Muscle and Renal Blood Flow under Euglycemic Conditions2000 · 26 citations
  2. 2Angiotensin II Enhances Insulin-Stimulated Whole-Body Glucose Disposal but Impairs Insulin-Induced Capillary Recruitment in Healthy Volunteers2010 · 28 citations
  3. 3Angiotensin II enhances insulin sensitivity in healthy volunteers under euglycemic conditions1993 · 37 citations
  4. 4Angiotensin II induces insulin resistance independent of changes in interstitial insulin1999 · 104 citations
  5. 5Angiotensin Mediates Forearm Glucose Uptake by Hemodynamic Rather Than Direct Effects1996 · 41 citations