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November 1, 1999AJP Endocrinology and Metabolism

Angiotensin II induces insulin resistance independent of changes in interstitial insulin

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Why the study?

Does angiotensin II infusion alter insulin action and interstitial insulin in anesthetized dogs?

Population

Anesthetized dogs

Comparison

Hyperinsulinemic euglycemic clamps with… vs Hyperinsulinemic euglycemic clamps without…

Design

Preclinical

Authors

JRJoyce M. RicheyUniversity of Southern CaliforniaMAMarilyn AderHôpitaux Universitaires Henri-MondorDMDonna MooreUniversity of Pittsburgh

Discussion

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Implication

ANG II may induce insulin resistance independent of interstitial insulin in dogs; leaves open relevance to human hypertension and metabolic disease.

Structured PICO

Does angiotensin II infusion alter insulin action and interstitial insulin in anesthetized dogs?

P
Population
Anesthetized dogs
I
Intervention
Hyperinsulinemic euglycemic clamps with simultaneous infusions of angiotensin II (ANG II)
C
Comparator
Hyperinsulinemic euglycemic clamps without simultaneous infusions of angiotensin II
O
Outcome
Hemodynamic parameters, glucose turnover, and insulin dynamics in plasma and interstitial fluid (lymph)surrogate

Angiotensin II induces insulin resistance in a dog model through mechanisms independent of reductions in interstitial insulin.

Cite This Study

Richey et al. (1999) studied this question.

synapsesocial.com/papers/6a702b3f2163a0a01bc4630dhttps://doi.org/10.1152/ajpendo.1999.277.5.e920

Topics

Hypertension management
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low-Dose Angiotensin II Increases Glucose Disposal Rate During Euglycemic Hyperinsulinemia1993 · 23 citations
  2. 2Angiotensin Mediates Forearm Glucose Uptake by Hemodynamic Rather Than Direct Effects1996 · 41 citations
  3. 3Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.1985 · 1,483 citations
  4. 4Estimation of Endogenous Glucose Production During Hyperinsulinemic-Euglycemic Glucose Clamps: Comparison of Unlabeled and Labeled Exogenous Glucose Infusates1987 · 541 citations