Angiotensin II Enhances Insulin-Stimulated Whole-Body Glucose Disposal but Impairs Insulin-Induced Capillary Recruitment in Healthy Volunteers
Why the study?
Does Angiotensin II coinfusion alter insulin-induced capillary recruitment and whole-body glucose uptake in healthy subjects during hyperinsulinemia?
Population
18 healthy subjects
Comparison
Systemic hyperinsulinemia with coinfusion of… vs Basal state, systemic hyperinsulinemia alone…
Design
Other
Authors
Discussion
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Member takes
Implication
Challenges microvascular mediation of insulin action; leaves open relevance to insulin resistance or outcomes.
Structured PICO
Does Angiotensin II coinfusion alter insulin-induced capillary recruitment and whole-body glucose uptake in healthy subjects during hyperinsulinemia?
P
Population
18 healthy subjects
I
Intervention
Systemic hyperinsulinemia with coinfusion of Angiotensin II
C
Comparator
Basal state, systemic hyperinsulinemia alone, and hyperinsulinemia with coinfusion of phenylephrine (pressor control)
O
Outcome
Skin capillary density, capillary recruitment, capillary density during venous congestion, whole-body glucose uptake, and blood pressuresurrogate
Angiotensin II enhances insulin-mediated glucose uptake in healthy individuals despite reducing insulin-mediated skin capillary recruitment, suggesting the mechanism is independent of increased microvascular perfusion.
Cite This Study
Jonk et al. (2010) studied this question.