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December 1, 1994Diabetes

Pressor and Subpressor Doses of Angiotensin II Increase Insulin Sensitivity in NIDDM: Dissociation of Metabolic and Blood Pressure Effects

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Why the study?

Does angiotensin II infusion improve insulin sensitivity in normotensive patients with NIDDM?

Population

11 normotensive patients with non-insulin-dependent diabetes mellitus (NIDDM)

Comparison

3-hour infusion of subpressor and pressor doses… vs Placebo infusion

Design

RCT, Randomized, crossover design, Double-blind

Follow-up

3 hours

Authors

AMAndrew D. MorrisCentre for Human GeneticsJPJohn R. PetrieUniversità Cattolica del Sacro CuoreSUShinichiro UedaGeneral / Preventive / Lipids

Discussion

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Implication

Acute angiotensin II infusion enhances insulin sensitivity in normotensive type 2 diabetes; extends RAS effects on glucose metabolism independent of blood pressure.

Structured PICO

Does angiotensin II infusion improve insulin sensitivity in normotensive patients with NIDDM?

P
Population
11 normotensive patients with non-insulin-dependent diabetes mellitus (NIDDM)
I
Intervention
3-hour infusion of subpressor (low dose) and pressor (high dose) doses of angiotensin II
C
Comparator
Placebo infusion
O
Outcome
Whole body insulin sensitivity measured using the euglycemic hyperinsulinemic clampsurrogate

Acute infusion of angiotensin II increases insulin sensitivity in normotensive patients with NIDDM, independent of its blood pressure effects.

Cite This Study

Morris et al. (1994) studied this question.

synapsesocial.com/papers/6a71f12a35aa2c282ce302fahttps://doi.org/10.2337/diab.43.12.1445
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Angiotensin II on Insulin Sensitivity: A Placebo-Controlled Study1993 · 14 citations
  2. 2Angiotensin II enhances insulin sensitivity in healthy volunteers under euglycemic conditions1993 · 37 citations
  3. 3Altered action of angiotensin II in patients with type 2 diabetes mellitus of recent onset1997 · 16 citations
  4. 4Angiotensin II Affects Basal, Pulsatile, and Glucose-Stimulated Insulin Secretion in Humans1997 · 55 citations
  5. 5Angiotensin II induces insulin resistance independent of changes in interstitial insulin1999 · 104 citations