Why the study?
Does hyperinsulinaemia alter the cardiovascular responses to graded hypovolaemia in normal and diabetic subjects?
Population
12 subjects total: 5 normal male subjects and 7 diabetic subjects with peripheral and autonomic neuropathy.
Comparison
Hyperinsulinaemic, euglycaemic clamp. vs Placebo clamp using 0.9% NaCl and pre-clamp…
Design
Single blind (for the first experiment)
Authors
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May increase hypotension risk during hypovolaemia in diabetic neuropathy; leaves open prospective validation before clinical application.
Does hyperinsulinaemia alter the cardiovascular responses to graded hypovolaemia in normal and diabetic subjects?
Hyperinsulinaemia alters cardiovascular compensatory responses to hypovolaemia differently in normal subjects compared to diabetic patients with autonomic neuropathy, potentially predisposing the latter to hypotension.
Scott et al. (1988) studied this question.
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