Key result
High-dose insulin infusion (up to 64 IU/kg/h) increased cardiac output and regional blood flow, particularly in femoral and carotid beds, suggesting positive inotropic and vasodilating effects.
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High-dose insulin may improve perfusion experimentally; leaves open translation to human shock or heart failure.
Reikerås et al. (1986) studied Healthy dogs (n=10). Insulin was evaluated on Systemic haemodynamics and regional blood flows. High-dose insulin infusion (up to 64 IU/kg/h) increased cardiac output and regional blood flow, particularly in femoral and carotid beds, suggesting positive inotropic and vasodilating effects.
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