Key result
Insulin infusion into the cerebral circulation of dogs produced no changes in heart rate, arterial pressure, or other measured cardiovascular variables.
Why the study?
Does insulin infusion into the cerebral circulation increase heart rate and arterial pressure in conscious dogs?
Population
Conscious dogs chronically instrumented for continuous infusions and measurement of arterial pressure…
Comparison
Insulin infusion into the cerebral circulation… vs Glucose or saline infusion in the absence of…
Design
Preclinical
Follow-up
up to 4 days
Authors
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Does not support central insulin effects on hemodynamics in dogs; hypothesis-generating for peripheral mediation of sympathetic activation.
Does insulin infusion into the cerebral circulation increase heart rate and arterial pressure in conscious dogs?
Insulin does not appear to increase heart rate or arterial pressure via direct effects on the central nervous system in dogs, suggesting previously observed sympathetic activation may be secondary to peripheral actions.
Hildebrandt et al. (1999) studied this question. Insulin infusion into the carotid or vertebral artery vs. Glucose or saline infusion was evaluated on Heart rate, arterial pressure, cardiac output, and other hemodynamic variables. Insulin infusion into the cerebral circulation of dogs produced no changes in heart rate, arterial pressure, or other measured cardiovascular variables.
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