Why the study?
Does chronic central nervous system hyperinsulinemia decrease food intake and raise arterial pressure in rats?
Population
Male Sprague-Dawley rats (n=17)
Comparison
Chronic intracerebroventricular insulin infusion… vs Vehicle ICV infusion for 7 days
Design
Preclinical
Follow-up
7 days
Authors
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Central insulin fails to sustain appetite or BP effects in rats; leaves open its role in human cardiometabolic disease.
Does chronic central nervous system hyperinsulinemia decrease food intake and raise arterial pressure in rats?
Chronic central nervous system hyperinsulinemia does not play a major role in the long-term regulation of appetite, arterial pressure, or heart rate in rats.
Liu et al. (2006) studied this question.
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