Why the study?
Does acute infusion of insulin into the brain ventricles increase the gain of baroreflex control of heart rate and lumbar sympathetic nerve activity in urethane-anesthetized rats?
Population
Urethane-anesthetized rats (males and females)
Comparison
Acute infusion of insulin into the brain… vs Baseline/control and fourth ventricular infusion
Design
Preclinical
Follow-up
60 to 90 minutes
Authors
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Central insulin effects on baroreflex gain in rats extend animal autonomic data; leaves open human hypertension relevance.
Does acute infusion of insulin into the brain ventricles increase the gain of baroreflex control of heart rate and lumbar sympathetic nerve activity in urethane-anesthetized rats?
Acute infusion of insulin into the forebrain (lateral ventricle) enhances the gain of baroreflex control of heart rate and lumbar sympathetic nerve activity in rats.
Pricher et al. (2007) studied this question.
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