Why the study?
Does anteroventral third ventricle lesion abolish lumbar sympathetic responses to hyperinsulinemia in rats?
Population
Fasted, anesthetized rats (sham-lesioned and anteroventral third ventricle-lesioned), n=44
Comparison
Intravenous insulin infusion at 0.13 U/h during… vs Vehicle infusion
Design
Preclinical
Follow-up
Acute (during infusion)
Authors
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Lesions of the anteroventral third ventricle abolish insulin-induced sympathetic activation in rats; leaves open any role in human hypertension.
Does anteroventral third ventricle lesion abolish lumbar sympathetic responses to hyperinsulinemia in rats?
Lesions of the anteroventral third ventricle abolish the increase in lumbar sympathetic nerve activity induced by systemic insulin infusion in rats.
Muntzel et al. (1994) studied this question.
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