Key result
Hyperinsulinemia increases lumbar sympathetic nerve activity by activating a glutamatergic NMDA-dependent projection to the rostral ventrolateral medulla.
Population
alpha-chloralose anesthetized, male Sprague-Dawley rats
Design
Preclinical
Follow-up
120 minutes
Authors
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May link hyperinsulinemia to sympathetic hypertension; hypothesis-generating and requires human validation before any clinical consideration.
Hyperinsulinemia increases lumbar sympathetic nerve activity via activation of a glutamatergic NMDA-dependent projection to the rostral ventrolateral medulla.
Bardgett et al. (2010) studied Hyperinsulinemia. Hyperinsulinemic-euglycemic clamps and microinjection of glutamatergic receptor antagonists was evaluated on lumbar sympathetic nerve activity (SNA) and arterial blood pressure (ABP). Hyperinsulinemia increases lumbar sympathetic nerve activity by activating a glutamatergic NMDA-dependent projection to the rostral ventrolateral medulla.
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