Key result
In obese Zucker rats, enhanced angiotensinergic activation and reduced GABAergic inhibition of the rostral ventrolateral medulla contribute to elevated sympathetic nerve activity and mean arterial pressure.
Population
124 male rats (14-18 weeks old), comprising 65 obese Zucker rats (OZR) and 59 lean Zucker rats (LZR)
Comparison
Microinjections of muscimol, losartan… vs Lean Zucker rats receiving identical…
Design
Preclinical
Authors
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Animal data implicate brainstem mechanisms in obese rat hypertension; leaves open human translation and should not change practice.
p-value: p=<0.05
Elevated sympathetic nerve activity and mean arterial pressure in obese Zucker rats are driven by enhanced angiotensinergic activation and reduced GABAergic inhibition of the rostral ventrolateral medulla.
Huber et al. (2011) studied Obesity-induced hypertension (n=124). RVLM microinjections (muscimol, losartan, kynurenate, gabazine) vs. Lean Zucker rats was evaluated on Changes in splanchnic sympathetic nerve activity (SNA), heart rate (HR), and mean arterial pressure (MAP) (p=<0.05). In obese Zucker rats, enhanced angiotensinergic activation and reduced GABAergic inhibition of the rostral ventrolateral medulla contribute to elevated sympathetic nerve activity and mean arterial pressure.
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