Key result
Acute increases in cerebrospinal fluid NaCl concentrations selectively activate a discrete population of RVLM neurons through glutamate receptor activation to increase SNA and arterial blood pressure.
Population
Preclinical model undergoing single-unit recordings of spinally projecting rostral ventrolateral medulla…
Comparison
Lateral ventricle infusion of 0.15 mol/L, 0.6… vs Baseline or lower concentrations of NaCl
Design
Preclinical
Authors
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Elucidates a central pathway for salt-induced sympathetic activation; leaves open relevance to human hypertension.
Acute increases in cerebrospinal fluid NaCl concentrations selectively activate a discrete population of RVLM neurons through glutamate receptor activation to increase sympathetic nerve activity and blood pressure.
Stocker et al. (2015) studied Salt-sensitive hypertension. Cerebrospinal fluid hypernatremia (lateral ventricle infusion of NaCl) was evaluated on Sympathetic nerve activity and arterial blood pressure. Acute increases in cerebrospinal fluid NaCl concentrations selectively activate a discrete population of RVLM neurons through glutamate receptor activation to increase SNA and arterial blood pressure.
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