Population
Male Sprague-Dawley rats fed normal chow
Comparison
Access to 0.9% NaCl solution for 14 days vs Access to water for 14 days
Design
Preclinical
Follow-up
14 days
Authors
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May inform mechanisms of salt-sensitive hypertension; leaves open translation to human disease or therapy.
Elevated dietary salt enhances the sympathoexcitatory actions of Angiotensin II in the rostral ventrolateral medulla, providing mechanistic insight into salt-sensitive hypertension.
Adams et al. (2008) studied this question.
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