July 28, 2006The Journal of PhysiologyOpen Access

A spinal vasopressinergic mechanism mediates hyperosmolality‐induced sympathoexcitation

View Full Paper

Ask AI

Bookmark

Why the study?

Does hyperosmolality induce sympathoexcitation via a spinal vasopressinergic mechanism in rats?

Population

In vivo and in situ rat preparations

Comparison

Hypertonic saline or hyperosmotic perfusate with… vs Baseline/control conditions prior to intervention

Design

Preclinical

Authors

VAVagner Roberto AntunesUniversidade de São Paulo SYS. T. YaoUniversity of Bristol APAnthony E. PickeringUniversity of Bristol

Discussion

Member takes

Implication

Spinal V1a receptors mediate hyperosmotic sympathoexcitation in rats; leaves open translation to human salt-sensitive hypertension.

Structured PICO

Does hyperosmolality induce sympathoexcitation via a spinal vasopressinergic mechanism in rats?

Population

In vivo and in situ rat preparations

Intervention

Hypertonic saline (HS, i.v. bolus) or hyperosmotic perfusate (135 mm NaCl or 0.5% mannitol) with various pharmacological blockades (prazosin, isoguvacine, kynurenic acid, V1a receptor antagonist) or surgical transections

Comparator

Baseline/control conditions prior to intervention

Outcome

Mean arterial pressure (MAP) and lumbar sympathetic nerve activity (LSNA)surrogate

Acute salt loading produces sympathetically mediated hypertension in rats, which is mediated by vasopressin acting on spinal V1a receptors.

Cite This Study

Antunes et al. (2006) studied this question.

synapsesocial.com/papers/6a7b75d014b028facf0ed61c https://doi.org/10.1113/jphysiol.2006.115766

View Full Paper

Ask AI

Bookmark

A spinal vasopressinergic mechanism mediates hyperosmolality‐induced sympathoexcitation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A spinal vasopressinergic mechanism mediates hyperosmolality‐induced sympathoexcitation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider