Key result
Hyperosmotic activation of CNS sympathetic drive, mediated by forebrain OVLT neurons, may contribute to the elevation of sympathetic nerve activity in salt-sensitive cardiovascular diseases.
Design
Review
Authors
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Hypothesis-generating for salt-sensitive hypertension mechanisms; prospective trials needed before clinical translation.
This review highlights the role of OVLT neurons in osmosensory activation of sympathetic drive, providing potential mechanistic insights into salt-sensitive cardiovascular diseases.
Toney et al. (2010) conducted a review in Salt-sensitive cardiovascular diseases. Hyperosmotic activation of CNS sympathetic drive was evaluated. Hyperosmotic activation of CNS sympathetic drive, mediated by forebrain OVLT neurons, may contribute to the elevation of sympathetic nerve activity in salt-sensitive cardiovascular diseases.
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