What is the clinical evidence from this study?

Study design: Other. Population: Chronic hyperinsulinemia and hypertension (n=16). Intervention: Insulin infusion vs. Control period. Primary outcome: Mean arterial pressure (MAP).

What question did this study set out to answer?

This research aims to assess whether chronic hyperinsulinemia influences blood pressure or interacts with angiotensin II effects.

March 1, 1990AJP Renal Physiology

Chronic hyperinsulinemia and blood pressure regulation

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Key result

Chronic hyperinsulinemia via insulin infusion did not elevate mean arterial pressure (102 vs 106 mmHg control) in dogs with reduced kidney mass or potentiate the hypertensive effects of ANG II.

Why the study?

Does chronic hyperinsulinemia elevate mean arterial pressure or potentiate the hypertensive effects of angiotensin II in dogs with reduced kidney mass?

Population

Conscious dogs with kidney mass reduced by 70% (n=16)

Comparison

Insulin infusion for 7 to 28 days with plasma… vs Control period prior to insulin infusion

Design

Preclinical

Follow-up

7 to 28 days

Authors

JHJohn E. HallCanadian Institute for Advanced Research TCT. G. ColemanUniversity of Mississippi HMH. L. MizelleOrlando Regional Medical Center

Discussion

Member takes

Implication

Does not implicate chronic hyperinsulinemia in hypertension in this model; leaves open alternative mechanisms of obesity-associated hypertension.

Key Points

This research aims to assess whether chronic hyperinsulinemia influences blood pressure or interacts with angiotensin II effects.
Insulin infusion (0.5 or 1.0 mU.kg-1.min-1 iv) over 7 or 28 days in conscious dogs with reduced kidney mass.
Dogs received varying sodium intakes (138 meq/day and 319 meq/day) to evaluate effects on blood pressure and hormonal levels.
Measurements included mean arterial pressure, plasma insulin levels, plasma renin activity, and glomerular filtration rate.
Insulin infusion did not increase MAP, with averages of 106 +/- 2 mmHg during control and 102 +/- 2 mmHg during infusion.
Chronic hyperinsulinemia resulted in transient sodium and potassium retention but did not affect plasma renin or aldosterone.
Insulin did not enhance MAP in the presence of ANG II infusion, indicating other factors contribute to obesity-related hypertension.

Structured PICO

Does chronic hyperinsulinemia elevate mean arterial pressure or potentiate the hypertensive effects of angiotensin II in dogs with reduced kidney mass?

Population

Conscious dogs with kidney mass reduced by 70% (n=16)

Intervention

Insulin infusion (0.5 or 1.0 mU.kg-1.min-1 iv) for 7 to 28 days with plasma glucose held constant, with or without angiotensin II infusion

Comparator

Control period (baseline) prior to insulin infusion

Outcome

Mean arterial pressure (MAP)surrogate

Main Result

Absolute Event Rate: 102% vs 106%

Chronic hyperinsulinemia does not elevate mean arterial pressure or potentiate the hypertensive effects of angiotensin II in a dog model with reduced kidney mass, suggesting other factors cause obesity-associated hypertension.

Cite This Study

Hall et al. (1990) studied Chronic hyperinsulinemia and hypertension (n=16). Insulin infusion vs. Control period was evaluated on Mean arterial pressure (MAP). Chronic hyperinsulinemia via insulin infusion did not elevate mean arterial pressure (102 vs 106 mmHg control) in dogs with reduced kidney mass or potentiate the hypertensive effects of ANG II.

synapsesocial.com/papers/6a0808cd1e8b9db648ddeafc https://doi.org/10.1152/ajprenal.1990.258.3.f722

Topics

Hypertension management

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Implication

Does not implicate chronic hyperinsulinemia in hypertension in this model; leaves open alternative mechanisms of obesity-associated hypertension.

Chronic hyperinsulinemia and blood pressure regulation

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Topics

Chronic hyperinsulinemia and blood pressure regulation

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

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Topics

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