February 1, 1998Hypertension

Maintenance of Baseline Angiotensin II Potentiates Insulin Hypertension in Rats

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Population

Sprague-Dawley rats instrumented with artery and vein catheters (n=15)

Comparison

Angiotensin II clamped at baseline levels during… vs Vehicle infusion during the same 7-day IV…

Design

Preclinical

Follow-up

7 days

Authors

HKHenry L. KeenUniversity of Iowa MBMichael W. BrandsGeneral / Preventive / Lipids MSM. J. SmithJackson Memorial Hospital

Discussion

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Implication

Ang II may potentiate insulin-induced hypertension in rats; hypothesis-generating for mechanisms, with human relevance untested.

Structured PICO

Population

Sprague-Dawley rats instrumented with artery and vein catheters (n=15)

Intervention

Angiotensin II clamped at baseline levels (continuous IV benazepril 5 mg/kg/day + IV Ang II 5 ng/kg/min) during a 7-day IV infusion of insulin (1.5 mU/kg/min) and glucose (20 mg/kg/min)

Comparator

Vehicle infusion during the same 7-day IV infusion of insulin and glucose

Outcome

Mean arterial pressure (MAP)surrogate

Decreased Angiotensin II during insulin infusion limits the renal vasoconstrictor and hypertensive actions of insulin, partly via attenuation of renal thromboxane production.

Cite This Study

Keen et al. (1998) studied this question.

synapsesocial.com/papers/6a208be415e15183b6b57ffb https://doi.org/10.1161/01.hyp.31.2.637

Topics

Hypertension management

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Maintenance of Baseline Angiotensin II Potentiates Insulin Hypertension in Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Maintenance of Baseline Angiotensin II Potentiates Insulin Hypertension in Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider