Key result
Chronic insulin infusion for up to 28 days did not significantly increase mean arterial pressure or potentiate angiotensin II-induced hypertension in dogs.
Why the study?
Does chronic hyperinsulinemia cause sustained increases in mean arterial pressure or potentiate the hypertensive effects of angiotensin II in dogs?
Population
Dogs with reduced kidney mass maintained on high sodium intake, and dogs infused with angiotensin II to…
Design
Preclinical
Follow-up
7 to 28 days
Authors
Loading...
Does not support insulin as a direct driver of hypertension in dogs; leaves open alternative mechanisms in human obesity-related hypertension.
Does chronic hyperinsulinemia cause sustained increases in mean arterial pressure or potentiate the hypertensive effects of angiotensin II in dogs?
Chronic hyperinsulinemia does not directly cause or potentiate hypertension in canine models, indicating other mechanisms are responsible for obesity-associated hypertension.
Hall et al. (1989) studied Hypertension. Insulin infusion was evaluated on Sustained increases in mean arterial pressure (MAP). Chronic insulin infusion for up to 28 days did not significantly increase mean arterial pressure or potentiate angiotensin II-induced hypertension in dogs.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: