What does this research mean for the field?

Chronic hyperinsulinemia lowers blood pressure, increases cardiac output, and decreases total peripheral resistance, suggesting that insulin exerts a peripheral vasodilatory effect in addition to promoting renal sodium retention. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1991American Journal of Hypertension

The Hemodynamic Response to Chronic Hyperinsulinemia in Conscious Dogs

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Why the study?

Does chronic hyperinsulinemia alter hemodynamics in normal dogs?

Population

7 normal dogs

Comparison

Insulin infused at 1 mU/kg/min together with… vs Baseline/control levels

Design

Preclinical

Follow-up

7 days

Authors

MBMichael W. BrandsGeneral / Preventive / Lipids HMH. L. MizelleOrlando Regional Medical Center SGSandrine GaillardGoethe University Frankfurt

Discussion

Member takes

Implication

Does not support clinical translation; leaves open hemodynamic effects of hyperinsulinemia in humans.

Structured PICO

Does chronic hyperinsulinemia alter hemodynamics in normal dogs?

Population

7 normal dogs

Intervention

Insulin infused at 1 mU/kg/min together with glucose at 14 mg/kg/min for 7 days

Comparator

Baseline/control levels

Outcome

Hemodynamic effects (mean arterial pressure, cardiac output, total peripheral resistance)surrogate

Chronic hyperinsulinemia in normal dogs lowers blood pressure and increases cardiac output, suggesting a peripheral vasodilatory effect.

Cite This Study

Brands et al. (1991) studied this question.

synapsesocial.com/papers/6a19b9061d4d911c80ea8a64 https://doi.org/10.1093/ajh/4.2.164

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The Hemodynamic Response to Chronic Hyperinsulinemia in Conscious Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Hemodynamic Response to Chronic Hyperinsulinemia in Conscious Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider