What question did this study set out to answer?

This research aims to determine how chronic hyperinsulinemia affects hemodynamic and renal function in obese, insulin-resistant dogs compared to normal dogs.

May 1, 1995Hypertension

Hemodynamic and Renal Responses to Chronic Hyperinsulinemia in Obese, Insulin-Resistant Dogs

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Why the study?

Does chronic hyperinsulinemia elevate blood pressure in obese, insulin-resistant dogs?

Population

Instrumented conscious dogs, including normal dogs and dogs made obese and insulin resistant by feeding them…

Comparison

Insulin infusion (1.0 mU/kg per minute) for 7 days vs Normal insulin-sensitive dogs receiving the same…

Design

Preclinical

Follow-up

7 days

Authors

JHJohn E. HallCanadian Institute for Advanced Research MBMichael W. BrandsGeneral / Preventive / Lipids DZDion ZappeAlnylam Pharmaceuticals (United States)

Discussion

Member takes

Implication

May blunt hyperinsulinemia's pressor effects in obese models; leaves open mechanisms of obesity-related hypertension for further study.

Key Points

This research aims to determine how chronic hyperinsulinemia affects hemodynamic and renal function in obese, insulin-resistant dogs compared to normal dogs.
Evaluated normal and obese insulin-resistant dogs (N=12) over 7 days of insulin infusion (1.0 mU/kg per minute).
Measured systemic hemodynamics including arterial pressure, cardiac output, and heart rate.
Assessed insulin sensitivity using fasting hyperinsulinemia and hyperinsulinemic euglycemic clamp techniques.
Obese dogs showed increased body weight (from 24.0 kg to 40.9 kg) and arterial pressure (from 83 mm Hg to 106 mm Hg) post diet.
7 days of insulin infusion did not significantly change arterial pressure in obese dogs (average 106 mm Hg before and 102 mm Hg after), contrary to normal dogs.
Heart rate increased from 116 beats per minute to 135 beats per minute with no change in cardiac output in obese dogs.

Structured PICO

Does chronic hyperinsulinemia elevate blood pressure in obese, insulin-resistant dogs?

Population

Instrumented conscious dogs, including normal dogs (n=6) and dogs made obese and insulin resistant by feeding them a high-fat diet for 6 weeks (n=6)

Intervention

Insulin infusion (1.0 mU/kg per minute) for 7 days

Comparator

Normal insulin-sensitive dogs receiving the same insulin infusion, and baseline control periods

Outcome

Systemic hemodynamics (arterial pressure, heart rate, cardiac output, total peripheral resistance) and renal functionsurrogate

Chronic hyperinsulinemia does not elevate arterial pressure in obese, insulin-resistant dogs, suggesting that insulin resistance combined with hyperinsulinemia is not sufficient to cause hypertension in this model.

Cite This Study

Hall et al. (1995) studied this question.

synapsesocial.com/papers/6a2078b3fb035751fb317c4b https://doi.org/10.1161/01.hyp.25.5.994

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Hemodynamic and Renal Responses to Chronic Hyperinsulinemia in Obese, Insulin-Resistant Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Hemodynamic and Renal Responses to Chronic Hyperinsulinemia in Obese, Insulin-Resistant Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider