Key result
Insulin resistance correlated with mean arterial blood pressure (r=0.73 at high dose; p<0.05), while exogenous insulin similarly reduced fractional sodium excretion in both groups.
Why the study?
Does exogenous insulin affect fractional sodium excretion, blood pressure, and heart rate in non-insulin-dependent diabetics with and without hypertension?
Does exogenous insulin affect fractional sodium excretion, blood pressure, and heart rate in non-insulin-dependent diabetics with and without hypertension?
Absolute Event Rate: 62% vs 57%
Acute hyperinsulinemia induces sodium retention and a decline in blood pressure in non-insulin-dependent diabetics, suggesting that insulin resistance, rather than insulin itself, is primarily related to hypertension.
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Hypothesis-generating for insulin resistance in diabetic hypertension; leaves open causal role and therapeutic targeting.
Gans et al. (1992) studied Non-insulin-dependent diabetes mellitus (n=16). Insulin (euglycemic clamp technique) vs. Normotensive diabetics was evaluated on Reduction in fractional sodium excretion during high insulin dose. Insulin resistance correlated with mean arterial blood pressure (r=0.73 at high dose; p<0.05), while exogenous insulin similarly reduced fractional sodium excretion in both groups.
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