Why the study?
Does intracarotid glucose infusion alter the ACTH, vasopressin, and epinephrine responses to insulin-induced hypoglycemia in conscious dogs?
Population
Six conscious dogs with carotid loops
Comparison
Intracarotid glucose infusion following… vs Intracarotid saline infusion following injection…
Design
Preclinical
Follow-up
40 to 60 minutes
Authors
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Identifies carotid glucose sensors for ACTH/epinephrine responses in canine hypoglycemia; leaves open translation to human counterregulation.
Does intracarotid glucose infusion alter the ACTH, vasopressin, and epinephrine responses to insulin-induced hypoglycemia in conscious dogs?
Glucose receptors mediating ACTH and severe hypoglycemia-induced epinephrine responses are located within the carotid arterial circulation region.
Keller‐Wood et al. (1983) studied this question.
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