Key result
Intracoronary insulin induces coronary vasodilation in normal dogs but loses this effect in obese dogs.
Why the study?
The effects of graded intracoronary insulin infusion on cardiac hemodynamics and metabolism in normal versus obese states were not fully characterized.
Does graded intracoronary insulin infusion affect myocardial glucose uptake and coronary vasodilation differently in normal versus obese dogs?
Comparison
Normal dogs versus high-fat-fed obese dogs
Design
Preclinical study with graded intracoronary insulin infusion
Authors
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Caution against assuming preserved coronary insulin responses in obese patients; extends animal data but leaves open human translation.
Does graded intracoronary insulin infusion affect myocardial glucose uptake and coronary vasodilation differently in normal versus obese dogs?
p-value: p=<.01
Obesity induced by a high-fat diet in dogs impairs both the metabolic (glucose uptake) and hemodynamic (vasodilation) responses to intracoronary insulin.
Rocchini et al. (1996) studied Obesity (n=9). Graded intracoronary insulin infusion vs. Normal dogs / Baseline was evaluated on Coronary glucose extraction, coronary blood flow velocity, and coronary artery size (p=<.01). Graded intracoronary insulin infusion induced coronary vasodilation in normal dogs (vascular resistance index decreased to 0.72, P<.01), but this response was lost in obese dogs.
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